Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs)
نویسندگان
چکیده
منابع مشابه
Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily that exert their effects via type I and type II serine threonine kinase receptors and the SMAD intracellular signaling pathway to regulate diverse biologic processes. Recently, we discovered that the repulsive guidance molecule (RGM) family, including RGMA, RGMB, and RGMC/hemojuvelin (HJV), functio...
متن کامل03-P075 The repulsive guidance molecule (RGM) family in chicken
anism would thus be a new way to form a tube. As the generation of the lumen and of the tube itself requires the apparition of an apical domain, we decided to investigate how part of the lateral domain becomes apical. Our first results, using transgenes driven by brachyury regulating sequences, show that several proteins classically involved in antero-posterior and planar polarities could be in...
متن کاملBone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.
Bone Morphogenetic Proteins (BMPs) play crucial roles in a variety of developmental processes, but their functions during early vertebrate brain development are largely unknown. To investigate this problem, we have compared by in situ hybridization the expression of five Bmp genes belonging to the Drosophila Decapentaplegic (Bmp2 and Bmp4) and 60A subgroups (Bmp5, Bmp6 and Bmp7). Striking co-ex...
متن کاملEinsatz der Bone morphogenetic Proteins (BMPs) zur Behandlung von Pseudarthrosen – Effizienz und Therapieversagen Use of Bone Morphogenetic Proteins (BMPs) for the Treatment of Pseudarthroses – Efficiency and Therapy Failure
In der Therapie von Pseudarthrosen der proximalen Tibia kommen seit einigen Jahren die humanen rekombinanten „bone morphogenetic proteins“ (BMP-2 und BMP-7) zum Einsatz. Trotz limitiertem und spezifischem Einsatz als lokale Mediatoren der Knochenheilung können bisher keine Aussagen über den jeweiligen Erfolg der Therapie im Voraus getroffen werden. Die Regelmechanismen zeigen sich als wesentlic...
متن کاملThe role of Bone Morphogenetic Proteins (BMPs) in bone tissue engineering: a mini review
Bone tissue engineering is an emerging biomedical form to create a local environment which enables cells to promote the proliferation and differentiation for bone regeneration inductions. An essential contribution to bone formation and regeneration is given by growth factors such as platelet derived growth factor (PDGF), insulin-like growth factor (IGF), transforming growth factor (TGF), vascul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0046307